HKPMDC
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Hereditary Cancer
Test Name: Mismatch Repair Proteins Immunohistochemistry
Compliance:ASR
Test Description:This test is used to screen patients suspected to have an inherited cancer syndromes involving the DNA mismatch repair (MMR) process, such as Hereditary Non-Polyposis Colorectal Cancer (HNPCC / Lynch Syndrome) or confirm a clinical diagnosis. This test evaluates the expression of mismatch repair (MMR) proteins in tumor tissue by immunohistochemical (IHC) staining; absence of expression (no staining) for a particular protein suggests a molecular defect responsible for mismatch repair deficiency.
Methodology:Immunohistochemistry using the following antibodies - MLH, MSH2, MSH6 and PMS
Gene Name:MLH1/MSH2/MSH6/PMS2
Protein Name:DNA mismatch repair protein MLH1/DNA mismatch repair protein MSH2/DNA mismatch repair protein MSH6/Mismatch repair endonuclease PMS2
Specimen Requirements:FFPE Slide(s): 1 H&E stained slide and 10 unstained 10um thick FFPE slides (non-charged, non-coated) containing adequate amounts of tumor to be analyzed. Air dry. Do not oven dry. Please include a copy of corresponding surgical pathology report FFPE Block: Paraffin-embedded, formalin-fixed tissue block. Please include a copy of corresponding surgical pathology report
Storage Condition:Room Temperature
Turn Around Time:3-5 working days from day of specimen received
OMIM:
Genetic Home Reference:
Phone:+852.2986.1270
Fax:+852.2527.7028
E-mail:contact@hk-mpdc.com
27/F., Strand 50, No.50 Bonham Strand, Sheung Wan, Hong Kong
Opening Hours
Mondays to Fridays: 09:00-18:00
Saturdays: 09:00-16:00
Sundays and Public Holidays: Closed

For specimen pickup arrangements, please phone +852.2986.1270




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